Anti-CRP monoclonal antibody
- Product description
- Product background
- References cited
Product description:
Use recombinant CRP protein to immunize mice, fluorescently labeled probes and flow sorting technology to isolate a single B cell expressing anti-CRP monoclonal antibody, and amplify the code by PCR The nucleic acid sequence of the light and heavy chains of the anti-CRP monoclonal antibody protein was constructed and the recombinant plasmid was constructed. The plasmid was transfected into the Expi 293 eukaryotic expression system to prepare the anti-CRP monoclonal antibody protein.
Introduction to anti-CRP monoclonal antibodies
Source: Mouse
Protein type: Recombinant protein
Expression host: Expi 293
Product form: liquid
Type: IgG
Clonality: Monoclonal
Protein purity: >2mg/mL
Electrophoresis purity: >95%
We could not find any corresponding parameters, please add them to the properties table
背景
C-反应蛋白由五个24KDa原聚体（含206个氨基酸）以非共价连结成为五元体环形结构。C-反应蛋白会结合在死亡细胞或微生物外膜上的磷酸胆碱（phosphocholine），以激活补体系统。当体内有急性炎症、细菌感染、组织的损伤时，C-反应蛋白在数小时内出现，而疾病治愈后又很快就消失。C-反应蛋白并不仅限于单一疾病的诊断。它的临床价值主要在于组织损伤的筛检和监测，应用在判断病人是否发炎以及诊断发炎性疾病复发的可能性，藉以评估抗炎药物治疗的成效。由于具有很好的稳定性及精确性，可以是炎症和组织损伤的非特异性标志物。另外C-反应蛋白可用来协助类风湿性关节炎的诊断。
相关文献
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2.Koenig W, Khuseyinova N. Biomarkers of atherosclerotic plaque instability and rupture.[J]. Arteriosclerosis Thrombosis & Vascular Biology, 2007, 27(1):15-26.
3.Ridker P M. A Test in Context, : High-Sensitivity C-Reactive Protein[J]. Journal of the American College of Cardiology, 2016, 67(6):712.
4.Sang W, Dae J, Park, et al. Evaluation of fluorescence hs-CRP immunoassay for point-of-care testing[J]. Clinicachimica acta; international journal of clinical chemistry, 2005, 356(1-2):172.
5.Paz J C, West M P. Acute Care Handbook for Physical Therapists (Fourth Edition)[M]. 2013.
6.Pearson T A, Mensah G A, Alexander R W, et al. Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association[J]. Circulation, 2003, 107(3): 499-511.
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